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Evaluation of the Feasibility and Potential Impacts for Seattle Police Department Officers to Carry and Administer Naloxone for Opioid Overdose Reversal

Principal Investigator:
Caleb Banta-Green, PhD, MPH, MSW
Senior Research Scientist
Alcohol and Drug Abuse Institute
calebbg@u.washington.edu
http://bit.ly/adaistaff_bantagreen

Date: May 1, 2016 to April 30, 2017
Sponsor: Seattle Police Department
Categories: Overdose Prevention | Implementation Research


Description: This goals of this project are to 1) evaluate the feasibility and potential impacts of a Seattle Police Department Pilot Program, in cooperation with the Seattle Fire Department (SFD), to carry and administer naloxone for opioid overdose reversal; and 2) evaluate whether training police officers to recognize and respond to opioid overdoses impacts the health of those who have an opioid overdose, and/or impacts the officer’s perceptions of their role as a police officer or their perceptions of opioid addiction and opioid users.

A Hybrid Effectiveness-Implementation Trial of a School-Based Teen Marijuana Checkup

Principal Investigator:
Denise D. Walker, PhD
Rearch Associate Professor
Social Work
ddwalker@uw.edu

Date: May 15, 2016 to February 28, 2020
Sponsor: National Institute on Drug Abuse (1R01DA040650-01)
Categories: Marijuana | Implementation Research

Other Investigators: Multiple PI: Bryan Hartzler, PhD, ADAI Senior Research Scientist


Description: Marijuana is the most widely used illicit substance with approximately 25 million people in the U.S. having used marijuana in the past year. An estimated 10% of persons who have ever used marijuana will become daily users, with lifetime marijuana dependence rates estimated at 4% of the general population, the highest of any illicit drug. Given that the great majority of adults with one or more marijuana use disorder symptoms report they began smoking before age 18, early intervention efforts with adolescents, particularly those who are using heavily, becomes an important public health objective in order to prevent later problems.

The objectives of the proposed study are to advance Type 2 translational science through an effectiveness-implementation "type 2" hybrid design to evaluate the clinical and cost-effectiveness of an efficacious intervention (Teen Marijuana Check-Up, TMCU) and compare the feasibility, acceptability, impact and cost-effectiveness of two integrity monitoring support systems. Marijuana continues to be the most frequently used drug in the U.S. and adolescent use is associated with negative effects such as academic failure, dropout, and emotional problems. Although marijuana is the most common presenting substance for 12-17 year olds seeking substance abuse treatment, few voluntarily seek indicated services. The TMCU is a brief, school-based motivational enhancement therapy approach that has been systematically evaluated in three randomized controlled trials with reliable beneficial effects in prompting voluntary participation in the intervention and decreasing adolescent marijuana use.

With TMCU now well-positioned for broad dissemination, its public health impact may be enhanced by further research addressing: 1) to what extent its documented efficacy under controlled conditions translates to real-world effectiveness, and 2) what support systems are most useful in promoting sustained integrity in its delivery by the available school-based personnel. The proposed type 2 effectiveness/implementation hybrid trial will include randomization at multiple levels. Students will be randomly-assigned in a 1:2 ratio to `services-as-usual' and TMCU intervention conditions, and school-based personnel identified to deliver TMCU will be randomly-assigned to do so under governance of a `gold-standard' training/oversight support system (i.e., rapid, continual performance-based feedback and weekly coaching about integrity of TMCU delivery) or a less resource-intensive support system similarly including performance-based feedback but with process benchmarking (defined by prior performance of research interventionists in TMCU efficacy trials) prompting points at which these school-based personnel receive purveyor coaching. Expected trial participation of ten schools will enable recruitment of 30 TMCU interventionists, and access to a pool of 250 marijuana-using students during a two-year implementation period. This nested design (e.g., students in schools/intervention conditions; interventionists in schools/training/oversight support systems) will utilize multilevel models in study analyses to account for possible school-level clustering. A cost analysis will also be conducted. Longitudinal outcome and process data will be collected from school based staff (6, 12, 18, & 24 month follow-ups) and students (3 and 6 month follow- ups). The trial will occur in Washington state at an opportune time when legislative, fiscal, and socio-cultural factors converge to heighten potential adolescent exposure to marijuana-related harms-represents an effort by this investigative team to respond to such local challenges in a manner that will advance understanding of best practices for dissemination and implementation of this and other efficacious, school-based interventions.

Related Web Sites:
NIH RePORTER Record

Knowledge of and Attitudes about Medication Assisted Treatment within American Indian Communities

Principal Investigator:
Sandra M. Radin, PhD
Alcohol and Drug Abuse Institute
http://bit.ly/adaistaff_radin

Date: 2017
Sponsor: National Institute on Drug Abuse
Categories: American Indians / Alaska Natives | Implementation Research | CTN (NIDA Clinical Trials Network)

Other Investigators: Co-investigators: Dennis Donovan, Dennis Wendt


Description: This study, in partnership with two American Indian tribes in the Pacific Northwest, addresses critical barriers in the implementation of medication assisted treatment (MAT) for opioid use disorder (OUD). MAT approaches have been shown to substantially improve outcomes for OUD patients, yet provider and patient biases against MAT and organizational barriers to MAT use are widespread, particularly within tribal communities where there is a strong preference toward total abstinence as a goal. The study aim is to identify knowledge and perceptions of MAT approaches and barriers/facilitators for implementation and sustained use. Study results will inform future clinical efforts to tailor MAT for high need, low resource American Indian/Alaska Native (AIAN) populations.

Related Web Sites:
Protocol record in CTN Library

Washington State Innovation Initiative: Medication Assisted Treatment Upon Release from Prison

Principal Investigator:
Caleb Banta-Green, PhD, MPH, MSW
Senior Research Scientist
Alcohol and Drug Abuse Institute
calebbg@u.washington.edu
http://bit.ly/adaistaff_bantagreen

Date: August 1, 2016 to July 31, 2018
Sponsor: Laura and John Arnold Foundation
Categories: Overdose Prevention | Implementation Research

Other Investigators: Theresa Hoeft, PhD, Judith Tsui, PhD, Jeanne Sears, MD, MPH


Description: The goal of this study is to develop, implement, and assess the feasibility of procedures to provide effective services for offenders with OUD releasing from WA DOC prisons, with the aim to facilitate linkage to ongoing MAT in the community following release from custody beginning with an initial intervention aimed to educate inmates so they can make informed decisions regarding medication options.


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